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Perinatal mental illness: definition, description and aetiology
Perinatal mental illness is a significant complication of pregnancy and the postpartum period. These disorders include depression, anxiety disorders, and postpartum psychosis, which usually manifests as bipolar disorder. Perinatal 最佳 10 种加密货币交易应用程序评论 depression and anxiety are common, with prevalence rates for major and minor depression up to almost 20% during pregnancy and the first 3 months postpartum. Postpartum blues are a common but lesser manifestation of postpartum affective disturbance. Perinatal psychiatric disorders impair a woman's function and are associated with suboptimal development of her offspring. Risk factors include past history of depression, anxiety, or bipolar disorder, as well psychosocial factors, such as ongoing conflict with the partner, poor social support, and ongoing stressful life events. Early symptoms of depression, anxiety, and mania can be detected through screening in pregnancy and the postpartum period. Early detection and effective management 最佳 10 种加密货币交易应用程序评论 of perinatal psychiatric disorders are critical for the welfare of women and their offspring.
Keywords: perinatal 最佳 10 种加密货币交易应用程序评论 mental illness; postpartum anxiety disorders; postpartum depression; postpartum psychosis.
Copyright © 2013 Elsevier Ltd. All rights reserved.
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Optimal sample sizes for phase II clinical 最佳 10 种加密货币交易应用程序评论 trials and pilot studies
Methodology for sample size calculation for phase III clinical trials is well established and widely used. In contrast, for earlier phase clinical trials or pilot studies, although there is an acceptance that the 最佳 10 种加密货币交易应用程序评论 methods used for phase III trials are not appropriate, there is little consensus over methods that should be 最佳 10 种加密货币交易应用程序评论 used. This paper explores this problem from a Bayesian decision-theoretic perspective. The aim is to obtain sample sizes that would be appropriate for studies funded by a large funder such as a public sector body or major pharmaceutical company. The sample sizes obtained are optimal in that they minimise the average number of patients required 最佳 10 种加密货币交易应用程序评论 per successfully identified effective therapy or equivalently maximise the number of effective therapies successfully identified over a long 最佳 10 种加密货币交易应用程序评论 最佳 10 种加密货币交易应用程序评论 period. It is indicated that the number of patients included in a phase II clinical trial should be 最佳 10 种加密货币交易应用程序评论 最佳 10 种加密货币交易应用程序评论 approximately 0.03 times that planned to be included in the phase III study. This is similar to that proposed by other researchers in this area, though rather smaller than actually used for many phase II trials.
Copyright © 2011 John Wiley & Sons, Ltd.
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